St. Denis Medicalcreator Eric Ledgin addresses the possibility ofSuperstorestars America Ferrera and Ben Feldman guest starring on NBC’s newest workplace comedy. Themedical mockumentary was created bySuperstore’s Justin Spitzer and Ledginand follows the underfunded yet dedicated staff of St. Denis Hospital. WithSuperstorealumni Kaliko Kauahi, Josh Lawson, and Nico Santos featured in the series, audiences are wondering whether Ferrera and Feldman might eventually jointheSt. Denis Medicalcastin future guest appearances.

During an interview withScreenRantat the 2025SXSWFilm Festival,St. Denis Medicalco-creator and co-showrunner Ledgin, alongside Universal Television’s EVP of Comedy Development Jim Donnelly, discussed the possibility of theSuperstorealums joining the medical comedy. While there are no official plans yet,Ledgin made it clear that both Ferrera and Feldman would be welcome at any moment. Read Ledgin and Donnelly’s full comments below:

A composite image features Amy and Jonah first meeting in the Superstore pilot and Amy and Jonah kissing from the end of the series

Eric Ledgin:They’d always be invited. They’re both lovely and talented people, and we’ve been incredibly lucky and had some incredible guest stars this year, and there’s really no one that I wouldn’t want to come back and be curious to see what would happen with them, but yeah. Those guys are wonderful, andI would love to have them on if they’re watching.

What This Means for St. Denis Medical

More Guest Appearances Could Be On The Horizon

St. Denis Medical’s reviewsand viewership ratings have proven that the show is a success, and ​​​​​​Ledgin’s response indicates that the medical mockumentary has its doors open to welcome more familiar comedy veterans onto the show. Guest appearances from formerSuperstorestars already cement its connection to the beloved workplace sitcom. Given the series' mockumentary style and character-driven humor,Ferrera and Feldman’s appearances would feel like a natural addition to the show. AlthoughSt. Denis MedicalandSuperstoreare set in vastly different workplaces, their comedic sensibilities align perfectly.

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With theSt. Denis Medicalseason 2 renewal, the possibility of their cameo does not seem too far-fetched. SinceSuperstoreended in 2021, Ferrera has gone on to star in Greta Gerwig’sBarbie, earning an Academy Award nomination, while Feldman has continued working in TV and animation. While their schedules may be packed,their potential involvement inSt. Denis Medicalwould be a major eventfor those who enjoy the workplace comedy genre. WithSt. Denis Medicalstill in season 1, there’s plenty of room for creative ways to incorporate either star into the show.

The doctors of St. Denis Medical dancing in the hallway.

Our Take On Superstore Stars Joining St. Denis Medical

A Perfect Comedy Crossover

While a recurring role for Ferrera or Feldman probably won’t happen, a single-episode guest spot would be perfect. Their guest appearances could see them playing brand-new characters in the medical setting, either as patients or workers, and could potentially nod to theirSuperstoreroots. If the show continues to expand its guest roster, adding familiar faces from theSuperstoreuniverse and other beloved sitcoms would be a fantastic way to surprise and keep viewers engaged. Whether or not it happens,St. Denis Medicalhas alreadyestablished itself as a worthy addition to NBC’s long-running legacy of workplace sitcoms.

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